1-Naphthylamine → HCID 18354528, compound

HRID 429145Notes

Reaction equation

HRID 429145 reaction equation
[C:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([C:19]2[CH:20]=[C:21]([S:27]([Cl:30])(=[O:29])=[O:28])[CH:22]=[CH:23][C:24]=2[O:25][CH3:26])[CH2:15][CH2:14]1>CC(C)=O>[ClH:30].[CH3:26][O:25][C:24]1[CH:23]=[CH:22][C:21]([S:27]([NH:11][C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)(=[O:28])=[O:29])=[CH:20][C:19]=1[N:16]1[CH2:15][CH2:14][N:13]([CH3:12])[CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 86401-NaphthylamineHCID 541068083-(4-Methylpiperazin-1-yl)-4-methoxybenzene sulfonyl chloride

Product 1

HCID 18354528HCID 18354528, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

1-Naphthylamine (29 mg, 0.2 mmol) was added to a stirred solution of 3-(4-methyl-1-piperazinyl)-4-methoxybenzene sulfonyl chloride (D2) (60 mg, 0.2 mmol) in acetone (1 ml) at ambient temperature. After stirring, for 18 h, the precipitate was filtered off and washed with acetone and diethyl ether to afford the title compound (E1) as a cream solid (60 mg, 67%).

Workup

  1. filtrationthe precipitate was filtered off
  2. washwashed with acetone and diethyl ether

Sources & evidence

ORD record
ord-c22da2addc5b48629a246b385d0268bc
Source dataset
uspto-grants-2001_11
Patent number
US06316450B1

Reaction notes

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