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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 429232Generated: October 29, 2026

4-Methylpiperidine → 1-{3-[(4'-{[(2R,5R)-2,5-dimethylpyrrolidinyl]carbonyl}[1,1'-biphenyl]-4-yl)oxy]propyl}-4-methylpiperidine

https://huagongshe.com/reaction/429232

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylpiperidineHCID 69381—
Reactant(2R,5R)-1-{[4'-(3-chloropropoxy)[1,1'-biphenyl]-4-yl]carbonyl}-2,5-dimethylpyrrolidineHCID 70141087—
Product1-{3-[(4'-{[(2R,5R)-2,5-dimethylpyrrolidinyl]carbonyl}[1,1'-biphenyl]-4-yl)oxy]propyl}-4-methylpiperidineHCID 70141170—

Reaction Steps

The product from Example 4A and 4-methylpiperidine were processed as described in Example 10F to provide the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06316475B1
Source datasetuspto-grants-2001_11
ORD IDord-5101e155b2844d7288bc83d28807390c
Source noteuspto-grants-2001_11