4-Methylpiperidine → 1-{3-[(4'-{[(2R,5R)-2,5-dimethylpyrrolidinyl]carbonyl}[1,1'-biphenyl]-4-yl)oxy]propyl}-4-methylpiperidine

HRID 429232Notes

Reaction equation

HRID 429232 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[C@H:24]([CH3:25])[CH2:23][CH2:22][C@H:21]3[CH3:26])=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.[CH3:27][CH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:26][C@@H:21]1[CH2:22][CH2:23][C@@H:24]([CH3:25])[N:20]1[C:18]([C:15]1[CH:16]=[CH:17][C:12]([C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:31]3[CH2:32][CH2:33][CH:28]([CH3:27])[CH2:29][CH2:30]3)=[CH:7][CH:8]=2)=[CH:13][CH:14]=1)=[O:19]

Participants

3

Reactant 2

HCID 693814-MethylpiperidineHCID 70141087(2R,5R)-1-{[4'-(3-chloropropoxy)[1,1'-biphenyl]-4-yl]carbonyl}-2,5-dimethylpyrrolidine

Product 1

HCID 701411701-{3-[(4'-{[(2R,5R)-2,5-dimethylpyrrolidinyl]carbonyl}[1,1'-biphenyl]-4-yl)oxy]propyl}-4-methylpiperidine

Procedure

The product from Example 4A and 4-methylpiperidine were processed as described in Example 10F to provide the title compound.

Sources & evidence

ORD record
ord-5101e155b2844d7288bc83d28807390c
Source dataset
uspto-grants-2001_11
Patent number
US06316475B1

Reaction notes

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