Thionyl Chloride → 4'-(3-Chloropropoxy)[1,1'-biphenyl]-4-carbonyl chloride

HRID 429237Notes

Reaction equation

HRID 429237 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([OH:20])=O)=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.S(Cl)([Cl:23])=O>>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([Cl:23])=[O:20])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 183547594'-(3-chloropropoxy)[1,1'-biphenyl]-4-carboxylic Acid

Product 1

HCID 183547664'-(3-Chloropropoxy)[1,1'-biphenyl]-4-carbonyl chloride

Procedure

The product from Example 10C (3.5 g, 11.36 mmol) in thionyl chloride (25 mL) was heated at 90° C. for 4 hours. The solution was allowed to cool to ambient temperature and then the mixture was evaporated to dryness to provide the title compound.

Workup

  1. customthe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-1ca31dc1e04a4b4b977477ae4000b2cf
Source dataset
uspto-grants-2001_11
Patent number
US06316475B1

Reaction notes

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