HuagongsheHuagongshe Chemistry Print Report · For research reference only
Salicylaldehyde → Ethyl 3-(1-benzofuran-2-yl)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Salicylaldehyde | HCID 6998 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 4-chloroacetoacetate | HCID 69484 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Ethyl 3-(1-benzofuran-2-yl)-3-oxopropanoate | HCID 12777066 | — |
Reaction Steps
122 g of salicylaldehyde 1 and 350 g of potassium carbonate are dissolved in 2L of acetone. While stirring at room temperature, add slowly 165 g of ethyl 4-chloroacetoacetate 2 over a period of 2 hours. When addition is over, stir at reflux for another 4 hours. Cool to room temperature and filter. Wash the filtration cake with 0.5L of acetone. Evaporate the solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06316487B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-11ea5f792bcf4826bf05acdc88e89b0c |
| Source note | uspto-grants-2001_11 |