HRID429339

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13363

1-Chloro-2-(diethylamine)ethane hydrochloride

C6H15Cl2N

HCID14798

Sodium Hydroxide

HNaO

结构：CCC(C)OC(=O)CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1

HCID18355456

未命名化合物

PRODUCTS

生成物

结构：CCC(C)OC(=O)CCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1

HCID10212316

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID66133

未命名化合物

溶剂HCID962

Water

H2O

2 次

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

619 g of compound 7 and 180 g of diethylaminoethyl chloride, hydrochloride salt, are dissolved in 2L of methylene chloride and 500 ml of water. To this add 23 g of benzyltriethylammonium chloride and 80 g of sodium hydroxide in 2L of water. Stir vigorously for 5 hours. Keep the organic phase. Wash with 1 L of water. Dry over sodium sulfate. Filter. Evaporate.

WORKUP

后处理

washWash with 1 L of water
dry with materialDry over sodium sulfate
filtrationFilter
customEvaporate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0cc6024e745a4b90bb1bdda087cd3c9e
来源数据集: uspto-grants-2001_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06316487B1
来源说明: uspto-grants-2001_11

反应 SMILES

[I:1][C:2]1[CH:3]=[C:4]([CH:25]=[C:26]([I:29])[C:27]=1[OH:28])[C:5]([C:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[O:9][C:8]=1[CH2:16][CH2:17][C:18]([O:20][CH:21]([CH2:23][CH3:24])[CH3:22])=[O:19])=[O:6].Cl.[CH2:31]([N:33]([CH2:36][CH2:37]Cl)[CH2:34][CH3:35])[CH3:32].[OH-].[Na+]>C(Cl)Cl.O.[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1>[I:29][C:26]1[CH:25]=[C:4]([CH:3]=[C:2]([I:1])[C:27]=1[O:28][CH2:32][CH2:31][N:33]([CH2:36][CH3:37])[CH2:34][CH3:35])[C:5]([C:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[O:9][C:8]=1[CH2:16][CH2:17][C:18]([O:20][CH:21]([CH2:23][CH3:24])[CH3:22])=[O:19])=[O:6]