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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 429343Generated: October 30, 2026

Potassium Carbonate → 2-[2-(3-Fluoro-4-methylphenyl)thioethyl]-1-methylpyrrolidine

https://huagongshe.com/reaction/429343

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant2-(2-Chloroethyl)-1-methylpyrrolidineHCID 285093—
Reactant3-Fluoro-4-methoxythiophenolHCID 2759007—
SolventDimethylformamideHCID 6228—
Product2-[2-(3-Fluoro-4-methylphenyl)thioethyl]-1-methylpyrrolidineHCID 1835546874.2%

Reaction Steps

2-(2-Chloroethyl)-1-methylpyrrolidine (1.4 g, 9.48 mmole), 3-fluoro-4-methyoxythiophenol (1.5 g, 9.48 mmole), potassium carbonate (13.1 g, 94.8 mmole) and DMF (20 mL) were combined, yielding 1.90 g (7.03 mmole, 74%) of the desired compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06316490B1
Source datasetuspto-grants-2001_11
ORD IDord-83062447b23f41e7aa7b4e0f3cf0fb3a
Source noteuspto-grants-2001_11