反应详情

Into a solution of n-butyl lithium (165 ml, 264 mmol) in butyl ether (250 ml) at −78 degrees under nitrogen was added 3-bromopyridine (25.4 ml, 264 mmol). After 1 h, added diethylmethoxyborane (52 ml, 396 mmol). The mixture was allowed to warm to room temperature. After 16 h, added water and brine, separated organic layer, dried over sodium sulfate, then concentrated. The resulting slurry was dissolved in isopropanol (500 ml), cooled and the product isolated by filtration give diethyl(3-pyridyl)borane (29.8 g).

1. waitAfter 16 h
2. customseparated organic layer
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. dissolutionThe resulting slurry was dissolved in isopropanol (500 ml)
6. temperaturecooled
7. customthe product isolated by filtration