反应详情

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 5-phenyl-oxazole-4-carboxylic acid {2-[2-(1-hydroxy-ethyl)-oxazol-5-ylmethyl]-2H-[1,2,3]triazol-4-yl}-amide (60 mg, 0.16 mmol) in AcCN (1.6 mL) was treated at rt with MnO2 (114 mg, 1.18 mmol) and the reaction mixture was stirred at rt overnight before being filtered through Celite. The solvent was removed under reduced pressure and the residue was dissolved in EA (10 mL), washed with water (10 mL), and brine. The org. layer was dried over MgSO4, filtered, and the solvents were removed under reduced pressure to give the title compound as a white foam. LC-MS-conditions 02: tR=0.97 min; [M+H]+=379.06.

1. filtrationbefore being filtered through Celite
2. customThe solvent was removed under reduced pressure
3. dissolutionthe residue was dissolved in EA (10 mL)
4. washwashed with water (10 mL), and brine
5. dry with materiallayer was dried over MgSO4
6. filtrationfiltered
7. customthe solvents were removed under reduced pressure