HCID 131722989, compound → (+,-) cis 7-Hydroxy-4-[4-(6-morpholinohexyloxy)-phenyl]-3-phenyl-chroman

HRID 429455Notes

Reaction equation

HRID 429455 reaction equation
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C@H:13]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][N:38]4[CH2:43][CH2:42][O:41][CH2:40][CH2:39]4)=[CH:27][CH:26]=3)[C@H:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:15][O:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>Cl.C(O)C.[Pd]>[OH:8][C:9]1[CH:18]=[C:17]2[C:12]([C@H:13]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][N:38]4[CH2:39][CH2:40][O:41][CH2:42][CH2:43]4)=[CH:27][CH:26]=3)[C@H:14]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:15][O:16]2)=[CH:11][CH:10]=1

Participants

5

Reactant 1

HCID 131722989HCID 131722989, compound

Product 1

HCID 131722988(+,-) cis 7-Hydroxy-4-[4-(6-morpholinohexyloxy)-phenyl]-3-phenyl-chroman

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

(+,−) cis 7-Benzyloxy-4-[4-(6-morpholinohexyloxy)-phenyl]-3-phenyl-chroman (150 mg, 0.26 mmol) was dissolved in a solution of 1% Hydrochloride in ethanol (5 ml). The solution was added to a 10% palladium on carbon catalyst, and hydrogenated (1 atm.) overnight. The reaction mixture was filtered and evaporated to give an oil which solidified.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated
  3. customto give an oil which

Sources & evidence

ORD record
ord-a69b92baaf65475dbf46409391b20c5a
Source dataset
uspto-grants-2001_11
Patent number
US06316494B1

Reaction notes

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