3-(Trifluoromethoxy)cinnamic Acid → (E)-N-[2-(4-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide

HRID 42958Notes

Reaction equation

HRID 42958 reaction equation
[CH3:1][C:2]1([C:7]2[N:8]=[C:9]([CH2:12][N:13]3[N:17]=[C:16]([NH2:18])[CH:15]=[N:14]3)[S:10][CH:11]=2)[O:6]CCO1.[F:19][C:20]([F:34])([F:33])[O:21][C:22]1[CH:23]=[C:24](/[CH:28]=[CH:29]/[C:30](O)=[O:31])[CH:25]=[CH:26][CH:27]=1>>[C:2]([C:7]1[N:8]=[C:9]([CH2:12][N:13]2[N:17]=[C:16]([NH:18][C:30](=[O:31])/[CH:29]=[CH:28]/[C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([O:21][C:20]([F:33])([F:34])[F:19])[CH:23]=3)[CH:15]=[N:14]2)[S:10][CH:11]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 7358403-(Trifluoromethoxy)cinnamic AcidHCID 673651222-[4-(2-Methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine

Product 1

HCID 42644626(E)-N-[2-(4-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide

Procedure

Following general procedure A followed by B, starting from 2-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine and (E)-3-(3-trifluoromethoxy-phenyl)-acrylic acid.

Sources & evidence

ORD record
ord-6fa6e6097f62454faebed042bd856ef6
Source dataset
uspto-grants-2013_09
Patent number
US08536209B2

Reaction notes

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