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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42958Generated: October 27, 2026

3-(Trifluoromethoxy)cinnamic Acid → (E)-N-[2-(4-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamide

https://huagongshe.com/reaction/42958

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethoxy)cinnamic AcidHCID 735840—
Reactant2-[4-(2-Methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamineHCID 67365122—
Product(E)-N-[2-(4-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(3-trifluoromethoxy-phenyl)-acrylamideHCID 42644626—

Reaction Steps

Following general procedure A followed by B, starting from 2-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine and (E)-3-(3-trifluoromethoxy-phenyl)-acrylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536209B2
Source datasetuspto-grants-2013_09
ORD IDord-6fa6e6097f62454faebed042bd856ef6
Source noteuspto-grants-2013_09