Methanimidamide, hydrochloride (1:1) → HCID 178524252, compound

HRID 429668Notes

Reaction equation

HRID 429668 reaction equation
C([C:3]1[C:4]([NH2:15])=[C:5]([C:12](O)=[O:13])[C:6](=[CH:10][CH:11]=1)[C:7]([OH:9])=[O:8])C.Cl.[CH:17](N)=[NH:18]>C(O)C>[OH:13][C:12]1[C:5]2[C:6]([C:7]([OH:9])=[O:8])=[CH:10][CH:11]=[CH:3][C:4]=2[N:15]=[CH:17][N:18]=1

Participants

4

Reactant 2

HCID 10313058Methanimidamide, hydrochloride (1:1)HCID 18355342HCID 18355342, compound

Product 1

HCID 178524252HCID 178524252, compoundYield 55.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 3-aminophthalic acid (1.00 g) in ethanol (10 ml) was added formamidine hydrochloride (444 mg) and refluxed for 12 hours. After cooling, the formed precipitate was collected by vacuum filtration and the precipitate was washed with ethanol to give 4-hydroxyquinazoline-5-carboxylic acid (504 mg).

Workup

  1. temperaturerefluxed for 12 hours
  2. temperatureAfter cooling
  3. filtrationthe formed precipitate was collected by vacuum filtration
  4. washthe precipitate was washed with ethanol

Sources & evidence

ORD record
ord-f2df6bd751af49a08fc15fe6930748cc
Source dataset
uspto-grants-2001_11
Patent number
US06316482B1

Reaction notes

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