反应详情

温度

50 °C

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of {2-[2-(1-hydroxy-ethyl)-oxazol-4-ylmethyl]-2H-[1,2,3]triazol-4-yl}-carbamic acid 2-chloro-benzyl ester (10 mg, 0.03 mmol) in AcCN (5.0 mL) was treated at rt with MnO2 (13 mg, 0.13 mmol) and the reaction mixture was stirred at 50° C. for 2 h before being filtered through Celite. TLC: rf (EA)=0.60. LC-MS-conditions 02: tR=0.97 min; [M+H]+=376.04.

1. filtrationbefore being filtered through Celite