Trifluoroacetic acid → HCID 20706100, compound

HRID 429754Notes

Reaction equation

HRID 429754 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C:9]1[O:13][C:12](=[O:14])[O:11][C:10]=1[CH2:15][O:16][C:17](=[O:30])[C@@H:18]1[CH2:22][CH2:21][CH2:20][N:19]1C(OC(C)(C)C)=O>C1(C)C=CC=CC=1>[CH3:8][C:9]1[O:13][C:12](=[O:14])[O:11][C:10]=1[CH2:15][O:16][C:17](=[O:30])[C@@H:18]1[CH2:22][CH2:21][CH2:20][NH:19]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 20706104HCID 20706104, compound

Product 1

HCID 20706100HCID 20706100, compoundYield 196.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Trifluoroacetic acid (2.5 ml) was added to the compound (38) (360 mg, 1.1 mmol) under ice-cooling and the resulting mixture was stood for 45 min. To the reaction mixture was added toluene and the mixture was concentrated in vacuo to give 490 mg of the compound (39). This compound was used in the next reaction without purification.

Workup

  1. temperaturecooling
  2. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-edbb8509e788444a9f910d3aed9c991d
Source dataset
uspto-grants-2001_11
Patent number
US06319902B1

Reaction notes

Loading…