Thionyl Chloride → 3-{2-[(Cyclohexylcarbonyl)amino]ethyl}-1-benzothiophene-5-carboxylic acid chloride

HRID 429774Notes

Reaction equation

HRID 429774 reaction equation
[CH:1]1([C:7]([NH:9][CH2:10][CH2:11][C:12]2[C:16]3[CH:17]=[C:18]([C:21]([OH:23])=O)[CH:19]=[CH:20][C:15]=3[S:14][CH:13]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:26])=O>>[CH:1]1([C:7]([NH:9][CH2:10][CH2:11][C:12]2[C:16]3[CH:17]=[C:18]([C:21]([Cl:26])=[O:23])[CH:19]=[CH:20][C:15]=3[S:14][CH:13]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 70029514HCID 70029514, compound

Product 1

HCID 881179513-{2-[(Cyclohexylcarbonyl)amino]ethyl}-1-benzothiophene-5-carboxylic acid chloride

Procedure

5 mmol of the product obtained in Step F are dissolved in 40 ml of thionyl chloride. After stirring under an inert atmosphere for 1 hour, the thionyl chloride is removed by evaporation under reduced pressure to yield the title product.

Workup

  1. customthe thionyl chloride is removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-37034ab8394948128f460be90d81532b
Source dataset
uspto-grants-2001_11
Patent number
US06319930B1

Reaction notes

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