Methanol → HCID 18007928, compound

HRID 429785Notes

Reaction equation

HRID 429785 reaction equation
CO.O.[OH-].[Na+].[C:6]([NH:9][CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:21]=1[CH:20]=[C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:37]=[C:36]3[C:31]([CH:32]=[CH:33][CH:34]=[C:35]3[CH2:38][C:39]([O:41]C)=[O:40])=[CH:30][CH:29]=1)[CH:18]=[CH:17]2)(=[O:8])[CH3:7]>C1COCC1>[C:6]([NH:9][CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:21]=1[CH:20]=[C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:37]=[C:36]3[C:31]([CH:32]=[CH:33][CH:34]=[C:35]3[CH2:38][C:39]([OH:41])=[O:40])=[CH:30][CH:29]=1)[CH:18]=[CH:17]2)(=[O:8])[CH3:7]

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 14798Sodium HydroxideHCID 46888521HCID 46888521, compound

Product 1

HCID 18007928HCID 18007928, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a 100 ml round-bottomed flask, dissolve the compound obtained in Example 43 in THF, and add methanol, water and sodium hydroxide. The reaction mixture is maintained at room temperature, with stirring, for 4 hours. Concentrate the solution, carry out hydrolysis and render acidic with concentrated hydrochloric acid. Suction off the resulting precipitate and recrystallise from a mixture of toluene/cyclohexane (4/1).

Workup

  1. concentrationConcentrate the solution
  2. customhydrolysis and render acidic with concentrated hydrochloric acid
  3. customSuction off the resulting precipitate and recrystallise from a mixture of toluene/cyclohexane (4/1)

Sources & evidence

ORD record
ord-649756114c774903828e4119cfdd4d64
Source dataset
uspto-grants-2001_11
Patent number
US06319930B1

Reaction notes

Loading…