Methane → HCID 15541455, compound

HRID 429790Notes

Reaction equation

HRID 429790 reaction equation
[CH:1]1([C:4]2[NH:12][C:11]3[C:10](=S)[NH:9][C:8](=[S:14])[N:7]([CH2:15][CH3:16])[C:6]=3[N:5]=2)[CH2:3][CH2:2]1.[CH2:17]([NH2:19])[CH3:18].C>O>[CH:1]1([C:4]2[NH:12][C:11]3[C:10]([NH:19][CH2:17][CH3:18])=[N:9][C:8](=[S:14])[N:7]([CH2:15][CH3:16])[C:6]=3[N:5]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 297MethaneHCID 6341EthylamineHCID 15907532HCID 15907532, compound

Product 1

HCID 15541455HCID 15541455, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

8-cyclopropyl-3-ethyl-2,6-dithioxanthine (20.19 g) prepared according to the method of example 2(i), and 70% ethylamine in water (320 ml 4.0M) were placed in a 450 ml pressure reactor and heated to 150° C. for 6 hours. The reaction solution was cooled to room temperature, treated with 2 portions of charcoal (0.2 g) filtered, and evaporated to dryness. The residue was triturated in menthol (300 ml), concentrated to about 200 ml, and the solid collected (16.48 g), mp 265° with decomposition.

Workup

  1. customwere placed in a 450 ml pressure reactor
  2. temperatureThe reaction solution was cooled to room temperature
  3. filtrationfiltered
  4. customevaporated to dryness
  5. customThe residue was triturated in menthol (300 ml)
  6. concentrationconcentrated to about 200 ml
  7. customthe solid collected (16.48 g), mp 265° with decomposition

Sources & evidence

ORD record
ord-7896411e87844555a62e99358533d5e8
Source dataset
uspto-grants-2001_11
Patent number
US06319928B1

Reaction notes

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