反应详情

A mixture of (S,S)-N-[2-(2,3-dihydrobenzofuran-5-yl)-1-methylethyl]-N-ethyl-(1-phenylethyl)amine (23 grams, 0.074 mole) and ammonium formate (30 grams, 0.48 mole) and 10% palladium on carbon (3.7 grams) in ethanol (300 ml) was heated under reflux for 2 hours. The mixture was filtered and the solvent was evaporated to give a residue which was partitioned between 5% sodium hydroxide and ether. Evaporation of the organic phase gave (S)-N-[2-(2,3-dihydrobenzofuran-5-yl)-1-methylethyl]ethylamine as an oil (14 grams, 92%), M+ 205.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. filtrationThe mixture was filtered
4. customthe solvent was evaporated
5. customto give a residue which
6. customwas partitioned between 5% sodium hydroxide and ether
7. customEvaporation of the organic phase