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HRID429834

反应详情

EQUATION

反应方程式

HRID 429834 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

结构：CS(=O)(=O)N1CCC(C=O)CC1
HCID10954372

1-(Methylsulfonyl)piperidine-4-carbaldehyde

C7H13NO3S

结构：CCN[C@@H](C)Cc1ccc2c(c1)CCO2
HCID11106515

未命名化合物

PRODUCTS

生成物

1
结构：CCN(CC1CCN(S(C)(=O)=O)CC1)[C@@H](C)Cc1ccc2c(c1)CCO2
HCID10927016

未命名化合物

收率 63%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(Cl)Cl
溶剂HCID6365

1,1-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

(S)-N-[2-(2,3-dihydrobenzofuran-5-yl)-1-methylethyl]ethylamine (24 grams, 0.117 mole) was dissolved in dichloroethane (300 ml) and sodium triacetoxyborohydride (37.2 grams, 0.176 mole) was added. After stirring for 5 minutes N-methanesulfonylpiperidine-4-carboxaldehyde (22.4 grams, 0.117 mole) was added and the mixture was stirred for another 2 hours. 5% sodium carbonate (600 ml) was added and the mixture was extracted with dichloromethane. Evaporation of the solvent gave an oil which was recrystallized from ether to give (S)-N-[2-(2,3,-dihydrobenzofuran-5-yl)-1-methylethyl]-N-ethyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine (28 grams, 63%), m.p. 99-101° C.

WORKUP

后处理

  1. additionwas added
  2. extractionthe mixture was extracted with dichloromethane
  3. customEvaporation of the solvent
  4. customgave an oil which
  5. customwas recrystallized from ether