反应详情

(S)-N-[2-(2,3,-Dihydrobenzofuran-5-yl)-1-methylethyl]-N-ethyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine (0.913 grams, 2.4 mmole) was dissolved in warm methanol (20 ml). To this solution was added 1.0M hydrogen chloride (2.5 ml) in ethyl ether. The solvent was removed under reduced pressure. The residue was dissolved in warm 2-butanone (3.0 ml). After 15 hours at 22° C., the crystals were collected and dried in vacuo to give (S)-N-[2-(2,3,-dihydrobenzofuran-5-yl)-1-methylethyl]-N-ethyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine hydrochloride (0.99 grams, 99%), m.p. 112-114° C., M+H 381.

1. customThe solvent was removed under reduced pressure
2. dissolutionThe residue was dissolved in warm 2-butanone (3.0 ml)
3. customthe crystals were collected
4. customdried in vacuo