Ammonium formate → HCID 54089766, 화합물

HRID 429842노트

반응식

HRID 429842 반응식
Cl.[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C@H:12]([N:14]([C@@H:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH3:19])[CH2:15][CH2:16][CH3:17])[CH3:13])=[CH:7][CH:6]=1)([O-])=O.C([O-])=O.[NH4+]>C(O)C.O.[Fe]>[NH2:2][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C@H:12]([N:14]([C@@H:18]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH3:19])[CH2:15][CH2:16][CH3:17])[CH3:13])=[CH:9][CH:10]=1

참가 물질

6

반응물 2

HCID 2723923Ammonium formateHCID 69143453HCID 69143453, 화합물

생성물 1

HCID 54089766HCID 54089766, 화합물

시약·촉매·용매 3

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

(R,R)-N-[2-(4-Nitrophenyl)-1-methylethyl]-N-propyl-(1-phenylethyl)amine hydrochloride was dissolved in ethanol (100 ml) and water (16 ml). To this solution was added iron powder (2.44 g) and ammonium formate (2.25 g). The mixture was heated at reflux for 3 hours, cooled to room temperature and filtered through a glass fiber filter. The filtrate was evaporated in vacuo, and the residue was partitioned between ethyl acetate and dilute sodium hydroxide. The organic layer was dried over sodium sulfate, filtered, and the solvent removed in vacuo to give (R,R)-N-[2-(4-aminophenyl)-1-methylethyl]-N-propyl-(1-phenylethyl)amine as a yellow syrup (2.9 g).

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 3 hours
  3. filtrationfiltered through a glass fiber
  4. filtrationfilter
  5. customThe filtrate was evaporated in vacuo
  6. customthe residue was partitioned between ethyl acetate and dilute sodium hydroxide
  7. dry with materialThe organic layer was dried over sodium sulfate
  8. filtrationfiltered
  9. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-7fc6cc474dcd4f29a83c0a9f7d3dddad
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06319920B1

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