Potassium Carbonate → HCID 69141675, compound

Participants

Reaction Conditions

Reaction Steps

N-[2-(4-aminophenyl)-1-methylethyl]-N-propyl-(1-methanesulfonyl-piperidin-4-ylmethyl)amine (60 mg) was dissolved in ethyl acetate (1 ml) and saturated potassium carbonate (1 ml). The mixture was cooled in an ice bath to 0° C. and morpholine-4-carbonyl chloride (0.03 ml) was added. After stirring for 30 minutes, the layers were separated. The organic layer was dried over magnesium sulfate, filtered, and the solvent removed to give N-{2-[4-(morpholine-4-carbonylamino)phenyl]-1-methylethyl]-N-propyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine (90 mg) as a foam, M+H 481.

Provenance & Evidence