Potassium Carbonate → HCID 69141675, compound

HRID 429845Notes

Reaction equation

HRID 429845 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([N:11]([CH2:15][CH:16]2[CH2:21][CH2:20][N:19]([S:22]([CH3:25])(=[O:24])=[O:23])[CH2:18][CH2:17]2)[CH2:12][CH2:13][CH3:14])[CH3:10])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[N:32]1([C:38](Cl)=[O:39])[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>C(OCC)(=O)C>[N:32]1([C:38]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([N:11]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([S:22]([CH3:25])(=[O:24])=[O:23])[CH2:20][CH2:21]3)[CH2:12][CH2:13][CH3:14])[CH3:10])=[CH:4][CH:3]=2)=[O:39])[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 848104-Morpholinecarbonyl chlorideHCID 18353050HCID 18353050, compound

Product 1

HCID 69141675HCID 69141675, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

N-[2-(4-aminophenyl)-1-methylethyl]-N-propyl-(1-methanesulfonyl-piperidin-4-ylmethyl)amine (60 mg) was dissolved in ethyl acetate (1 ml) and saturated potassium carbonate (1 ml). The mixture was cooled in an ice bath to 0° C. and morpholine-4-carbonyl chloride (0.03 ml) was added. After stirring for 30 minutes, the layers were separated. The organic layer was dried over magnesium sulfate, filtered, and the solvent removed to give N-{2-[4-(morpholine-4-carbonylamino)phenyl]-1-methylethyl]-N-propyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine (90 mg) as a foam, M+H 481.

Workup

  1. customthe layers were separated
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent removed

Sources & evidence

ORD record
ord-49f3ec5ed7054ee9b6fe4466d5cc5ab9
Source dataset
uspto-grants-2001_11
Patent number
US06319920B1

Reaction notes

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