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HRID429907

反应详情

EQUATION

反应方程式

HRID 429907 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CC(C)(C)OC(=O)N1[C@@H](Cc2cccc(C3CCC3)c2)C(=O)O[C@H](c2ccccc2)[C@@H]1c1ccccc1
HCID57135938

未命名化合物

PRODUCTS

生成物

1
结构：O=C1O[C@H](c2ccccc2)[C@H](c2ccccc2)N[C@H]1Cc1cccc(C2CCC2)c1
HCID57005921

未命名化合物

收率 91%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

According to example 82, 1.87 g of tert-butyl (2R, 3S, 5S)-6-oxo-2,3-diphenyl-5-(3-cyclobutylbenzyl)-4-morpholinecaboxylate was treated with 3.1 mL of TFA in 30 mL of CH2Cl2 for 4 h. Neutralization with 8 mL of Et3N and work-up in the usual manner gave a light yellow residue. Purification of the crude material by flash chromatography on 85 g of silica gel (8:2 hexane:EtOAc) afforded 1.35 g (91%) of (2R, 3S, 5S)-6-oxo-2,3-diphenyl-5-(3-cyclobutylbenzyl)morpholine as a thick, transparent semi-solid.

WORKUP

后处理

  1. customgave a light yellow residue
  2. customPurification of the crude material by flash chromatography on 85 g of silica gel (8:2 hexane:EtOAc)