Lithium Hydroxide → HCID 18353833, compound

HRID 430030Notes

Reaction equation

HRID 430030 reaction equation
[OH-].[Li+].[O:3]=[C:4]([NH:18][CH2:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)[CH2:5][O:6][C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][CH:8]=1>CO>[O:3]=[C:4]([NH:18][CH2:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:11]([OH:13])=[O:12])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 18353831HCID 18353831, compound

Product 1

HCID 18353833HCID 18353833, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.17 g of lithium hydroxide was added to a methanol (30 ml) solution including 1 g (3.2 mmole) of ethyl 4-{2-oxo-2-[(pyridin-3-ylmethyl)amino]ethoxy}benzoate, and reaction was then carried out at 60° C. for 2 hours. After the solvent had been removed, the residue was dissolved in water and then neutralized with hydrochloric acid, and the deposited solid was collected by filtration, washed with water, and then dried to obtain 0.73 g (yield: 79%) of 4-{2-oxo-2-[(pyridin-3-ylmethyl)amino]ethoxy}benzoic acid.

Workup

  1. customAfter the solvent had been removed
  2. dissolutionthe residue was dissolved in water
  3. filtrationthe deposited solid was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-198886a31e354d6eafbc52f813195b36
Source dataset
uspto-grants-2001_11
Patent number
US06320078B1

Reaction notes

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