反应详情

To a solution of (S)—N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide (6.0 mg, 14 μmol) in DCM (3 mL) was added DAST (0.3 mL, 14 μmol). The whole was stirred at room temperature overnight before the reaction mixture was quenched by the addition of water (2 mL). The organics were filtered through a hydrophobic frit before being concentrated to dryness and the residue purified by basic preparative HPLC to give the title compound (1.0 mg, 2.4 μmol, 17%). MS (ESI): m/z [M−H]− 418.0

1. customwas quenched by the addition of water (2 mL)
2. filtrationThe organics were filtered through a hydrophobic frit
3. concentrationbefore being concentrated to dryness
4. customthe residue purified by basic preparative HPLC