(Diethylamino)sulfur trifluoride → HCID 44555668, compound

Participants

Reaction Steps

To a solution of (S)—N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide (6.0 mg, 14 μmol) in DCM (3 mL) was added DAST (0.3 mL, 14 μmol). The whole was stirred at room temperature overnight before the reaction mixture was quenched by the addition of water (2 mL). The organics were filtered through a hydrophobic frit before being concentrated to dryness and the residue purified by basic preparative HPLC to give the title compound (1.0 mg, 2.4 μmol, 17%). MS (ESI): m/z [M−H]− 418.0

Provenance & Evidence