反应详情

A solution of 2-[(2-aminocyclopentyl)methylamino]-4-methoxyquinoline (0.090 g, 0.332 mmol) in hydrochloric acid (10M, 5 ml) was stirred at reflux for 8 h. After cooling the mixture was concentrated to give the title compound as a light brown solid (50:50 mixture of cis and trans isomers; 0.11 g, 100%). δH (CD3OD) 1.45-2.80 (7H, m, (CH2)3, CHCH2NH), 3.40-3.95 (3H, m, CHNH2, CH2NH), 6.43-6.45 (1H, 2s, 3-H), 7.47-8.18 (4H, m, ArH). MS (ES+) 258 (M+H).

1. temperatureat reflux for 8 h
2. temperatureAfter cooling the mixture
3. concentrationwas concentrated