Hydrochloric Acid → HCID 178495961, compound

HRID 430084Notes

Reaction equation

HRID 430084 reaction equation
[NH2:1][CH2:2][CH:3]([O:18][CH3:19])[CH2:4][NH:5][C:6]1[CH:15]=[C:14]([O:16]C)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1.[ClH:20]>>[ClH:20].[ClH:20].[NH2:1][CH2:2][CH:3]([O:18][CH3:19])[CH2:4][NH:5][C:6]1[CH2:15][C:14](=[O:16])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 183536912-(3-Amino-2-methoxyprop-1-ylamino)-4-methoxyquinoline

Product 1

HCID 178495961HCID 178495961, compoundYield 85%

Procedure

A solution of 2-(3-amino-2-methoxyprop-1-ylamino)-4-methoxyquinoline (0.84 g, 0.00321 mol) in hydrochloric acid (10M, 30 ml) was stirred at reflux for 24 h. After cooling the mixture was concentrated to give the title compound as a light brown solid (0.88 g, 85%). δH (CD3OD) 3.00-3.90 (5H, m, 2CH2, CHOCH3), 3.36 (3H, s, CHOCH3), 6.48 (1H, s, 3-H), 7.47-8.15 (4H, m, ArH). MS (ES+) 248 (M+H).

Workup

  1. temperatureat reflux for 24 h
  2. temperatureAfter cooling the mixture
  3. concentrationwas concentrated

Sources & evidence

ORD record
ord-ec68cfb5ea784e78a2e745ae12f8ca86
Source dataset
uspto-grants-2001_11
Patent number
US06320051B1

Reaction notes

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