2-Phenylethanol → HCID 131723000, compound

Participants

Reaction Conditions

Reaction Steps

Dichloromethylvinylsilane (80 g, 0.567 moles) was added to a stirred solution of phenethyl alcohol (140 g, 114 moles), triethylamine (TEA, 121 g, 1.2 moles) and Isopar C (700 mL) over one hour during which time the reaction mixture was heated to 70° C. After an additional one hour, the reaction was cooled to room temperature, filtered, concentrated in vacuo and then stripped under high vacuum distilled (110° C./4 mm Hg) to give product (1.66 g, 94%).

Provenance & Evidence