2-Phenylethanol → HCID 131723000, compound

HRID 430391Notes

Reaction equation

HRID 430391 reaction equation
Cl[CH:2]([CH:4]=[CH:5][SiH3:6])Cl.[CH2:7]([OH:15])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(N([CH2:21][CH3:22])CC)C>>[CH2:7]([O:15][CH:2]([CH:4]=[CH:5][SiH3:6])[O:15][CH2:7][CH2:8][C:22]1[CH:21]=[CH:11][CH:10]=[CH:9][CH:14]=1)[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 3

HCID 60542-PhenylethanolHCID 8471TriethylamineHCID 57347243HCID 57347243, compound

Product 1

HCID 131723000HCID 131723000, compoundYield 94%

Conditions

Temperature
70 °C

Procedure

Dichloromethylvinylsilane (80 g, 0.567 moles) was added to a stirred solution of phenethyl alcohol (140 g, 114 moles), triethylamine (TEA, 121 g, 1.2 moles) and Isopar C (700 mL) over one hour during which time the reaction mixture was heated to 70° C. After an additional one hour, the reaction was cooled to room temperature, filtered, concentrated in vacuo and then stripped under high vacuum distilled (110° C./4 mm Hg) to give product (1.66 g, 94%).

Workup

  1. temperaturethe reaction was cooled to room temperature
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo
  4. distillationdistilled (110° C./4 mm Hg)

Sources & evidence

ORD record
ord-7e32d0d9bfa94b68931a9f28ace4a48b
Source dataset
uspto-grants-2001_11
Patent number
US06322777B1

Reaction notes

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