反应详情

Methyl iodide (22.0 ml) was added to a stirred suspension of 4-methyl-2-(N-methylsulphonylamino)benzoic acid (8.0 g) and anhydrous potassium carbonate (24.2 g) in acetone and the mixture was stirred and heated at reflux overnight. The mixture was cooled and filtered and the filtrate was evaporated to dryness. The residue was dissolved in dichloromethane and washed with aqueous sodium bicarbonate solution, water, dried (magnesium sulphate) and filtered. The filtrate was evaporated to dryness to give methyl 4-methyl-2-(N-methyl-N-methylsulphonylamino)benzoate (8.36 g) as a cream solid, m.p. 100-103° C.

1. temperatureheated
2. temperatureat reflux overnight
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. customthe filtrate was evaporated to dryness
6. dissolutionThe residue was dissolved in dichloromethane
7. washwashed with aqueous sodium bicarbonate solution, water
8. dry with materialdried (magnesium sulphate)
9. filtrationfiltered
10. customThe filtrate was evaporated to dryness