反应详情

A solution of 4.89 g (20 mmol) of 9d in 1N methanolic HCl (75 mL) was heated at reflux for 2 hours. The reaction was diluted with water (50 mL) and the methanol was removed by concentration, in vacuo. The aqueous residue was extracted with ether (2×75 mL). The combined organic extracts were dried over Na2SO4 and concentrated, in vacuo, to provide the product as a yellow oil (3.93 g, 97% yield).

1. temperatureat reflux for 2 hours
2. customthe methanol was removed by concentration, in vacuo
3. extractionThe aqueous residue was extracted with ether (2×75 mL)
4. dry with materialThe combined organic extracts were dried over Na2SO4
5. concentrationconcentrated, in vacuo