HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 430603Generated: October 31, 2026
Water → n-({1-[2-(Benzofuran-3-yl)ethyl]-4-piperidyl}methyl)-n-methylamine
https://huagongshe.com/reaction/430603
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(Benzofuran-3-ylacetyl)-n-methyl-4-piperidinecarboxamide | HCID 15512385 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | n-({1-[2-(Benzofuran-3-yl)ethyl]-4-piperidyl}methyl)-n-methylamine | HCID 15512386 | — |
Reaction Steps
7.6 g of lithium aluminium hydride are added in portions to a solution of 28.7 g of the product obtained in Step C in 1.5 litres of tetrahydrofuran heated at 60°C. After 18 hours at reflux, the reaction mixture is hydrolysed by the addition of 5.24 ml of water, 4.2 ml of 20% sodium hydroxide solution and then 19.2 ml of water. After filtration, drying and concentration under reduced pressure, the expected product is isolated. The hydrochloride thereof recrystallises from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06323217B2 |
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| Source dataset | uspto-grants-2001_11 |
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| ORD ID | ord-fbfa6618b2eb4e50963005041e31c705 |
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| Source note | uspto-grants-2001_11 |
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