Sulfuric Acid → HCID 18351338, compound

HRID 430608Notes

Reaction equation

HRID 430608 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:13]1[CH2:22][CH2:21][C:16]2(OCC[O:17]2)[CH2:15][CH2:14]1.S(=O)(=O)(O)O>O1CCCC1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][C:16](=[O:17])[CH2:21][CH2:22]1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 69708186HCID 69708186, compound

Product 1

HCID 18351338HCID 18351338, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 6 g of the product of Step A, 60 ml of 10% sulphuric acid and 30 ml of tetrahydrofuran is heated at 50° C. for 12 hours, and then evaporated. The residue is taken up in ether, rendered basic with 20% sodium hydroxide solution, extracted with ethyl acetate, dried and evaporated, enabling the expected product to be isolated.

Workup

  1. customevaporated
  2. extractionextracted with ethyl acetate
  3. customdried
  4. customevaporated
  5. customto be isolated

Sources & evidence

ORD record
ord-7e8484a075c34fcdaabdcc3856993d5d
Source dataset
uspto-grants-2001_11
Patent number
US06323217B2

Reaction notes

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