3-(2-Bromoethyl)-5-fluorobenzofuran → 4-(Aminomethyl)-1-[2-(5-fluoro-benzofuran-3-yl)ethyl]-4-piperidinol

HRID 430611Notes

Reaction equation

HRID 430611 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[C:7]([CH2:10][CH2:11][N:12]3[CH2:17][CH2:16][C:15]([CH2:19][NH:20]C(=O)OCC)([OH:18])[CH2:14][CH2:13]3)[C:6]=2[CH:26]=1.FC1C=CC2OC=C(CCBr)C=2C=1>>[NH2:20][CH2:19][C:15]1([OH:18])[CH2:16][CH2:17][N:12]([CH2:11][CH2:10][C:7]2[C:6]3[CH:26]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=3[O:9][CH:8]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 181842963-(2-Bromoethyl)-5-fluorobenzofuranHCID 70198276ethyl N-{1-[2-(5-fluoro-benzofuran-3-yl)ethyl]-4-hydroxy-4-piperidylmethyl}carbamate

Product 1

HCID 183513564-(Aminomethyl)-1-[2-(5-fluoro-benzofuran-3-yl)ethyl]-4-piperidinol

Procedure

The product is obtained according to the process of Preparation 17, using ethyl N-{1-[2-(5-fluoro-benzofuran-3-yl)ethyl]-4-hydroxy-4-piperidylmethyl}carbamate as substrate, which is prepared as for the product of Step C of Preparation 16 starting from 2-(5-fluoro-benzofuran-3-yl)-1-bromoethane.

Workup

  1. customThe product is obtained
  2. customaccording to the process of Preparation 17

Sources & evidence

ORD record
ord-3fbd66f5df094705900e51ef13eaf0d3
Source dataset
uspto-grants-2001_11
Patent number
US06323217B2

Reaction notes

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