Benzyl chloroformate → HCID 18351249, compound

HRID 430630Notes

Reaction equation

HRID 430630 reaction equation
C(CC#N)(=O)C1C=CC=CC=1.[NH2:12][C:13]1[S:21][C:16]2[CH2:17][NH:18][CH2:19][CH2:20][C:15]=2[C:14]=1[C:22](=[O:30])[C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1.[CH2:31]([O:38][C:39](Cl)=[O:40])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[NH2:12][C:13]1[S:21][C:16]2[CH2:17][N:18]([C:39]([O:38][CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[O:40])[CH2:19][CH2:20][C:15]=2[C:14]=1[C:22](=[O:30])[C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 10387Benzyl chloroformateHCID 64799BenzoylacetonitrileHCID 18351257HCID 18351257, compound

Product 1

HCID 18351249HCID 18351249, compound

Procedure

Using the procedures in Examples 7 and 8, substituting p-fluorobenzoyl acetonitrile for benzoyl acetonitrile, 2-amino-3-(4-fluorobenzoyl)-4,5,6,7-tetrahydrothieno(2,3 -c)pyridine was prepared. This compound was reacted with benzyloxycarbonyl chloride to yield the title compound as a solid (mp 90-92° C). 1H NMR (CDCl3) 1.96 (m, 2H); 3.45 (m, 2H); 4.45 (s, 2H); 5.15 (s, 2H); 6.71 (bs, 2H); 7.05-7.52 (m, 9H).

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-b657fda90bca4a3387f86973185e67d2
Source dataset
uspto-grants-2001_11
Patent number
US06323214B1

Reaction notes

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