4-Methoxybenzaldehyde → n'-((4-Methoxyphenyl)methylidene)-3-phenyl-1h-indole-2-carbohydrazide

HRID 430644Notes

Reaction equation

HRID 430644 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[C:16]([NH:18][NH2:19])=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:20](=O)[C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1>C(O)C>[CH3:28][O:27][C:24]1[CH:25]=[CH:26][C:21]([CH:20]=[N:19][NH:18][C:16]([C:8]2[NH:9][C:10]3[C:15]([C:7]=2[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[O:17])=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 312444-MethoxybenzaldehydeHCID 27636583-phenyl-1H-indole-2-carbohydrazide

Product 1

HCID 70119851n'-((4-Methoxyphenyl)methylidene)-3-phenyl-1h-indole-2-carbohydrazide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of Example 1C (1.76 g, 7.0 mmol) and p-anisaldehyde (894 mL, 7.35 mmol) in ethanol (120 mL) was refluxed for 18 hours, cooled to room temperature, and filtered. The resulting solid was washed with ethanol and dried under vacuum to provide

Workup

  1. filtrationfiltered
  2. washThe resulting solid was washed with ethanol
  3. customdried under vacuum
  4. customto provide

Sources & evidence

ORD record
ord-7be6ad0b71b84507a82c542f892e03d4
Source dataset
uspto-grants-2001_11
Patent number
US06323228B1

Reaction notes

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