4-Bromobenzaldehyde → n'((4-Bromophenyl)methylidene)-3-phenyl-1h-indole-2-carbohydrazide

HRID 430645Notes

Reaction equation

HRID 430645 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[C:16]([NH:18][NH2:19])=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][C:21]1[CH:28]=[CH:27][C:24]([CH:25]=O)=[CH:23][CH:22]=1>C(O)C>[Br:20][C:21]1[CH:28]=[CH:27][C:24]([CH:25]=[N:19][NH:18][C:16]([C:8]2[NH:9][C:10]3[C:15]([C:7]=2[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[O:17])=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 707414-BromobenzaldehydeHCID 27636583-phenyl-1H-indole-2-carbohydrazide

Product 1

HCID 70129263n'((4-Bromophenyl)methylidene)-3-phenyl-1h-indole-2-carbohydrazide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of Example 1C (1.76 g, 7.0 mmol) and 4-bromobenzaldehyde (1.36 g, 7.35 mmol) in ethanol (120 mL) was refluxed for 18 hours, cooled to room temperature, and filtered. The resulting solid was washed with ethanol and dried under vacuum to provide

Workup

  1. filtrationfiltered
  2. washThe resulting solid was washed with ethanol
  3. customdried under vacuum
  4. customto provide

Sources & evidence

ORD record
ord-d621275b2cec4254b59c576f3b348f34
Source dataset
uspto-grants-2001_11
Patent number
US06323228B1

Reaction notes

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