反应详情

Methyl (7-methoxy-benzofuran-3-yl)acetate (1.12 g) was dissolved in methanol (20 ml). To this solution, 2N aqueous sodium hydroxide solution (5 ml) was added and the resulting solution was stirred at room temperature for 13.5 hours. To this solution, 1N hydrochloric acid (12 ml) was added and the reaction solution was poured into water layer (200 ml), followed by extraction twice with ethyl acetate (50 ml). The organic layers were combined and washed with saturated brine, followed by drying over sodium sulfate. Sodium sulfate was removed by filtration and the solvent was removed under reduced pressure. The residue was recrystallized from hexane/chloroform to obtain the desired compound (0.95 g, yield: 91%).

1. extractionfollowed by extraction twice with ethyl acetate (50 ml)
2. washwashed with saturated brine
3. dry with materialby drying over sodium sulfate
4. customSodium sulfate was removed by filtration
5. customthe solvent was removed under reduced pressure
6. customThe residue was recrystallized from hexane/chloroform