Hydrochloric Acid → (S)-2-Amino-3-(4-benzyloxy-phenyl)-N-tert-butyl-propionamide monohydrochloride

HRID 430805Notes

Reaction equation

HRID 430805 reaction equation
[NH2:1][C@@H:2]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)[C:3]([NH:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].[ClH:25]>CCOCC>[ClH:25].[NH2:1][C@@H:2]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:15][CH:16]=1)[C:3]([NH:5][C:6]([CH3:8])([CH3:7])[CH3:9])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15517727(S)-2-amino-3-(4-benzyloxy-phenyl)-N-tert-butyl-propionamide

Product 1

HCID 69584616(S)-2-Amino-3-(4-benzyloxy-phenyl)-N-tert-butyl-propionamide monohydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of (S)-2-amino-3-(4-benzyloxy-phenyl)-N-tert-butyl-propionamide (Example 1, Step B) in ether was added excess amount of ethereal HCl. The solid formed was isolated via filtration, and subsequent drying under vacuum gave (S)-2-Amino-3-(4-benzyloxy-phenyl)-N-tert-butyl-propionamide monohydrochloride as a yellow solid.

Workup

  1. customThe solid formed
  2. customwas isolated via filtration
  3. customsubsequent drying under vacuum

Sources & evidence

ORD record
ord-e482700996b648689fa8d2f92f820c73
Source dataset
uspto-grants-2001_11
Patent number
US06323243B1

Reaction notes

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