Hydrochloric Acid → HCID 12857528, compound

HRID 430899Notes

Reaction equation

HRID 430899 reaction equation
[OH-].[Na+].[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10].[CH2:11]([O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22])[CH:12]1[O:14][CH2:13]1.Cl>>[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:13][CH:12]([OH:14])[CH2:11][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8134Diethylene Glycol Monomethyl EtherHCID 14798Sodium HydroxideHCID 104422242-(2-methoxyethoxy)ethyl glycidyl ether

Product 1

HCID 12857528HCID 12857528, compoundYield 75%

Conditions

Temperature
70 °C

Procedure

44.0 g (1.1 mol) of NaOH pellets were added to 360 g (3.0 mol) of diethyleneglycol monomethyl ether, and 176 g (1.0 mol) of 2-(2-methoxyethoxy)ethyl glycidyl ether was gradually dropwise added while stirring at 70° C. After the completion of dropwise addition, the mixture was stirred for about one hour and then stood for cooling at room temperature. Then, the mixture was neutralized with hydrochloric acid, a precipitated salt was filtered off and the liquid was condensed. The liquid was purified by vacuum distillation to give 222 g of 1,3-bis[2-(2-methoxyethoxy)ethoxy]-2-propanol (yield: 75%). The distillation temperature was from 171 to 175° C./0.8 mmHg.

Workup

  1. additionwas gradually dropwise added
  2. additionAfter the completion of dropwise addition
  3. stirringthe mixture was stirred for about one hour
  4. temperaturefor cooling at room temperature
  5. filtrationa precipitated salt was filtered off
  6. customcondensed
  7. distillationThe liquid was purified by vacuum distillation

Sources & evidence

ORD record
ord-1408dede6baa48f59d66e4cb6804a746
Source dataset
uspto-grants-2003_12
Patent number
US06656252B2

Reaction notes

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