Trifluoroacetic acid → HCID 69837419, compound

HRID 430953Notes

Reaction equation

HRID 430953 reaction equation
C([O:5][C:6](=[O:47])[CH:7]([NH:11][C:12](=[O:46])[C:13]1[CH:18]=[CH:17][C:16]([CH2:19][N:20]2[C:25](=[O:26])[N:24]([CH3:27])[C:23]3[CH:28]=[CH:29][C:30]([C:32](=[O:43])[NH:33][CH2:34][C:35]4[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][CH:36]=4)=[CH:31][C:22]=3[S:21]2(=[O:45])=[O:44])=[CH:15][CH:14]=1)[CH:8]([CH3:10])[CH3:9])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[CH3:42][O:41][C:38]1[CH:37]=[CH:36][C:35]([CH2:34][NH:33][C:32]([C:30]2[CH:29]=[CH:28][C:23]3[N:24]([CH3:27])[C:25](=[O:26])[N:20]([CH2:19][C:16]4[CH:17]=[CH:18][C:13]([C:12]([NH:11][CH:7]([CH:8]([CH3:10])[CH3:9])[C:6]([OH:47])=[O:5])=[O:46])=[CH:14][CH:15]=4)[S:21](=[O:45])(=[O:44])[C:22]=3[CH:31]=2)=[O:43])=[CH:40][CH:39]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586175HCID 86586175, compound

Product 1

HCID 69837419HCID 69837419, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 0.18 g 2-{4-[7-(4-Methoxy-benzylcarbamoyl)-4-methyl-1,1,3-trioxo-3,4-dihydro-1l6-benzo[1,2,4]thiadiazin-2-ylmethyl]-benzoylamino}-3-methyl-butyric acid tert butyl ester (0.27 mmol, Step 1) was added 10 mL 50% trifluoroacetic acid in CHCl3 The resulting mixture was stirred 2 hours at room temperature, then concentrated. Obtained 0.14 g of the title compound as a solid from EtOAc/hexane. Anal. (C30H32N4O8S1) C,H,N. MS: M++1=609.4 Da

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-f6c45c60a6034d749f2150bdef060424
Source dataset
uspto-grants-2003_12
Patent number
US06656932B2

Reaction notes

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