Tetrabutylammonium Fluoride Trihydrate → HCID 18762640, compound
Reaction equation
[OH2:1].[OH2:2].[OH2:3].[F-].C([N+:9]([CH2:18][CH2:19][CH2:20][CH3:21])([CH2:14][CH2:15][CH2:16][CH3:17])CCCC)CCC>O1CCCC1>[OH:1][CH2:17][C:16]1[CH:15]=[CH:21][CH:20]=[CH:19][C:18]=1[NH:9][CH2:14][CH:15]1[CH2:16][CH2:17][C:18](=[O:2])[NH:9][C:14]1=[O:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
5 ml of a 1 M solution of tetrabutyl ammonium fluoride trihydrate in tetrahydrofuran were added to a solution of 0.20 g of the product from step 1 in 5 ml tetrahydrofuran. It was stirred for 3 h at 20° C., evaporated in vacuo and the residue was purified by flash chromatography on silica gel with ethyl acetate as eluent. 0.12 g (85% of theoretical) of the title compound were obtained in the form of a yellowish oil.
Workup
- customevaporated in vacuo
- customthe residue was purified by flash chromatography on silica gel with ethyl acetate as eluent
Sources & evidence
- ORD record
- ord-3fbe8d7a4e1d4c5e9a16880e69dcb80b
- Source dataset
- uspto-grants-2003_12
- Patent number
- US06656937B2
Reaction notes
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