Phosphorus oxychloride → HCID 11171710, compound

HRID 430993Notes

Reaction equation

HRID 430993 reaction equation
[O:1]1[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[NH:6][C:5](=O)[C:4]=2[CH:3]=[CH:2]1.O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:5]1[C:4]2[CH:3]=[CH:2][O:1][C:13]=2[C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[N:6]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 11389804HCID 11389804, compound2×

Product 1

HCID 11171710HCID 11171710, compound

Procedure

First, the known compound 5H-furo[3,2-c]quinolin-4-one (compound 1) is reacted with POCl3 to produce 4-chlorofuro[3,2-c]quinoline (compound 2). Compound 2 is further reacted with 3-aminoacetophenone in a solution of EtOH-H2 (2:1) to yield 1-[3-chlorofuro[3,2-c]quinolin-4-ylamino]phenyl)ethanone (compound 3).

Sources & evidence

ORD record
ord-361ffdada2fd4fc8b20ebf2ef967dc59
Source dataset
uspto-grants-2003_12
Patent number
US06656949B1

Reaction notes

Loading…