3-Chloro-4-fluoroaniline → HCID 18762747, compound

HRID 431016Notes

Reaction equation

HRID 431016 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:19][C:20]([CH3:22])=[O:21])=[C:9]([O:12][CH2:13][CH:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:23][C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][C:30]=1[F:31])[NH2:27]>C(O)(C)C>[Cl:23][C:24]1[CH:25]=[C:26]([NH:27][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:19][C:20]([CH3:22])=[O:21])=[C:9]([O:12][CH2:13][CH:14]4[CH2:18][CH2:17][CH2:16][CH2:15]4)[CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:28]=[CH:29][C:30]=1[F:31]

Participants

4

Reactant 2

HCID 97083-Chloro-4-fluoroanilineHCID 18762821HCID 18762821, compound

Product 1

HCID 18762747HCID 18762747, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4.03 g of 4-chloro-6-cyclopentylmethoxy-7-methylcarbonyloxy-quinazoline are suspended in 70 ml of isopropanol and 1.95 g of 3-chloro-4-fluoro-aniline are added. The reaction mixture is refluxed for two hours under a nitrogen atmosphere. After cooling to ambient temperature the light-coloured precipitate formed is suction filtered, washed with a little isopropanol and dried in the air.

Workup

  1. temperatureThe reaction mixture is refluxed for two hours under a nitrogen atmosphere
  2. customformed
  3. filtrationfiltered
  4. washwashed with a little isopropanol
  5. customdried in the air

Sources & evidence

ORD record
ord-ed3f7ee8342e4d7a895c265eaf80ecbd
Source dataset
uspto-grants-2003_12
Patent number
US06656946B2

Reaction notes

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