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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 431153Generated: October 25, 2026

1-Ethynyl-4-fluorobenzene → Z-4-fluorostyryl 2-chlorobenzylsulfide

https://huagongshe.com/reaction/431153

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethynyl-4-fluorobenzeneHCID 522627—
Reactant2-Chlorobenzyl mercaptanHCID 580759—
ReactantSodiumHCID 5360545—
ProductZ-4-fluorostyryl 2-chlorobenzylsulfideHCID 86588942—

Reaction Steps

A solution of 4-fluorophenylacetylene (0.02 mol) and 2-chlorobenzyl mercaptan (0.02 mol) and metallic sodium (0.02 g atom) was subjected to Procedure 2 to form (Z)-4-fluorostyryl 2-chlorobenzylsulfide. The title compound was obtained in 74% yield following oxidation. 1HNMR (CDC13) δ4.55 (2H, s), 6.66 (1H, d, JH,H=11.94), 7.20-7.65 (8H aromatic+1H ethylenic).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06656973B2
Source datasetuspto-grants-2003_12
ORD IDord-d57330e792bf444080d3a26cba83ac7b
Source noteuspto-grants-2003_12