反应详情

0.75 mol of aqueous sodium hydroxide solution (30%) are added to an aqueous solution of 0.5 mol of 2-nitro-6-(1-hydroxyethyl)-benzoic acid (sodium salt), and, at 90-95° C., 50 g of hydrazine hydrate (1.0 mol) are metered in over the course of 1 hour. Stirring is carried out at 90-95° C. for 4-6 hours until the nitro compound has been completely converted and, after isolation, 2-amino-6-(1-hydroxyethyl)-benzoic acid (sodium salt) is obtained in a yield of 97% of theory, based on 2-acetyl-6-nitrobenzoic acid (LC analysis).

1. customat 90-95° C.
2. customare metered in over the course of 1 hour