Hydrazine hydrate (1:1) → HCID 18763424, compound

HRID 431382Notes

Reaction equation

HRID 431382 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[Cl:22])[O:5][CH2:6][C:7]1[CH:8]=[C:9]([N+:16]([O-])=O)[CH:10]=[C:11]([N+:13]([O-])=O)[CH:12]=1.O.NN>CO.[Ni]>[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[Cl:22])[O:5][CH2:6][C:7]1[CH:8]=[C:9]([NH2:16])[CH:10]=[C:11]([NH2:13])[CH:12]=1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 187634315-(3,4-Dichlorophenoxymethyl)-1,3-dinitrobenzene

Product 1

HCID 18763424HCID 18763424, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

5-(3,4-dichlorophenoxymethyl)-1,3-dinitrobenzene in 5 ml MeOH was added to a solution of 10 ml 2.5 mmole hydrazine monohydrate and catalytic amount of Ra—Ni. The mixture was stirred under reflux for 30 min and then cooled to room temperature. GC-MS gave the peak of reduced product. The solution was filtered through Celite and MeOH was evaporated with rotaevaporation. The residue was used directly for next step without further purification.

Workup

  1. temperatureunder reflux for 30 min
  2. customGC-MS gave the peak of reduced product
  3. filtrationThe solution was filtered through Celite and MeOH
  4. customwas evaporated with rotaevaporation
  5. customThe residue was used directly for next step without further purification

Sources & evidence

ORD record
ord-c09c85f942a7469e92ec2d9fdf50c5f7
Source dataset
uspto-grants-2003_12
Patent number
US06656971B2

Reaction notes

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